Abstract
We have successfully identified a number of novel MTP inhibitors with single digit nanomolar potency. Analogues 10aq and 10dq demonstrated in vivo efficacy in a murine gut retention assay.
MeSH terms
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Administration, Oral
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Animals
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Anti-Obesity Agents / administration & dosage
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Anti-Obesity Agents / chemical synthesis*
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Anti-Obesity Agents / chemistry
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Anti-Obesity Agents / pharmacology*
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Carrier Proteins / antagonists & inhibitors*
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Carrier Proteins / metabolism
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Mice
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Molecular Structure
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Structure-Activity Relationship
Substances
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Anti-Obesity Agents
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Carrier Proteins
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microsomal triglyceride transfer protein